AVII - AVI Biopharma, Inc.

AVI BioPharma, Inc. (AVI) is a biopharmaceutical company specializing in the discovery and development of ribonucleic acid (RNA) based drugs targeting a range of diseases. The Companys core chemistry is based on phosphordiamidate-linked morpholino oligomers (PMOs). PMOs are synthetic molecules based on a fundamental redesign of the natural nucleic acid structure of deoxyribonucleic acid (DNA) and RNA. Translation Suppressing Oligomers (TSOs) are PMO-based antisense compounds that interfere with gene expression and other RNA-dependent cellular processes by binding to their specific target sequence in RNA. Splice Switching Oligomers (SSOs) are PMO-based compounds that can direct alternative splicing by forcing the cellular splicing machinery towards desired splicing outcomes, such as promoting the expression of a messenger RNA (mRNA) for desired protein.